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Future trials should therefore include body-composition assessment, muscle strength testing, physical performance measures, and rehabilitation adherence as core outcomes, rather than focusing only on body weight and pain ( 7.3 Perioperative management before arthroplasty Although current perioperative guidance emphasizes individualized assessment of GLP-1 receptor agonist use, KOA-specific perioperative pathways have not yet been established ( 7.4 Structural disease modification remains unproven in humans Perhaps the most important scientific limitation is that symptomatic improvement should not yet be interpreted as proof of structural disease modification

Together, these peptides activate your body's own repair systems rather than masking surface-level symptoms

Mitochondrial support: Protects mitochondrial membranes from oxidative damage